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GKT136901
Artikelnummer: Cay34205-10
GKT136901 is a dual inhibitor of NADPH oxidase 1 (NOX1) and NOX4 (Kis = 160 and 165 nM, respectively). It is selective for NOX1 and NOX4 over NOX2 and xanthine oxidase (Kis = 1,530 and >30,000 nM, respectively), as well as over a panel of 18 enzymes and ion channels at 10 µM. GKT136901 (0.1, 1, and 10 µM) scavenges...
| Schlagworte: | NOX Inhibitor IV, 2-(2-chlorophenyl)-4-methyl-5-(2-pyridinylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione |
| Anwendung: | NOX1 / NOX4 dual inhibitor |
| CAS | 955272-06-7 |
| MW: | 366.8 D |
ab 98,00 €
NEU
GKT136901
Artikelnummer: TGM-T8408-100mg
Description: GKT136901 (AK120765) is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite. Target: NADPH-oxidase, NADPH. Smiles: Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12. References: S Schildknecht, A Weber, H R Gerding.The NOX1/4 Inhibitor GKT136901 as Selective and Direct...
| Schlagworte: | AK120765 |
| Anwendung: | NOX1 / NOX4 dual inhibitor |
| CAS | 955272-06-7 |
| MW: | 366.8 D |
ab 30,00 €
