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PF-670462
Artikelnummer: TGM-T3073-100mg
Description: PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1epsilon in isolated enzyme preparations. Target: Casein Kinase. Smiles: Cl.Cl.Nc1nccc(n1)-c1c(ncn1C1CCCCC1)-c1ccc(F)cc1. References: Daniel I Perez, et al. Med Res Rev.2011,31(6):...
| Schlagworte: | PF670462 |
| Anwendung: | CK1 epsilon and CK1 delta inhibitor |
| CAS | 950912-80-8 |
| MW: | 410.32 D |
ab 42,00 €
PF-670462 (hydrochloride)
Artikelnummer: Cay14588-10
The casein kinase 1 (CK1) family of kinases regulate diverse processes, particularly related to circadian rhythms and sensitivity to amphetamines. PF-670462 is a potent inhibitor of the CK1 isoforms CK1epsilon and CK1delta (IC50 = 7.7 and 14 nM, respectively). It less effectively inhibits a wide variety of related...
| Schlagworte: | 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine, dihydrochloride |
| Anwendung: | CK1 epsilon and CK1 delta inhibitor |
| CAS | 950912-80-8 |
| MW: | 410.3 D |
ab 227,00 €
