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Isavuconazonium (sulfate)
Artikelnummer: Cay23950-1
Isavuconazonium is a prodrug form of the azole antifungal isavuconazole (ISA). Oral administration of isavuconazonium increases survival in rat models of azole-susceptible and -resistant A. fumigatus infection when administered at doses ranging from 0.25 to 512 mg/kg per day (ISA-equivalent = 0.12-245.8 mg/kg per...
| Schlagworte: | N-methyl-[2-[[[1-[1-[(2R,3R)-3-[4-(4-cyanophenyl)-2-thiazolyl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4H-1,2,4-triazolium-... |
| Anwendung: | Antifungal |
| CAS | 946075-13-4 |
| MW: | 814.8 D |
ab 93,00 €
Isavuconazonium sulfate
Artikelnummer: TGM-T3934-50mg
Description: Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), which catalyzes the demethylation of lanosterol to yield ergosterol, an important...
| Anwendung: | Targets sterol 14alpha-demethylase [EC:1.14.14.154 1.14.15.36] (CYP51) |
| CAS | 946075-13-4 |
| MW: | 814.84 D |
ab 65,00 €
