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BMS 303141
Artikelnummer: Cay16239-5
ATP citrate lyase (ACL) catalyzes the synthesis of acetyl-CoA and oxaloacetate using citrate, CoA, and ATP as substrates and Mg2+ as a cofactor. The ACL-dependent synthesis of acetyl-CoA is important for the de novo synthesis of fatty acids and cholesterol. Furthermore, as a key enzyme for linking glucose and lipid...
| Schlagworte: | 3,5-dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide |
| Anwendung: | ATP citrate lyase (ACL) inhibitor |
| CAS | 943962-47-8 |
| MW: | 424.3 D |
ab 144,00 €
BMS-303141
Artikelnummer: TGM-T2337-100mg
Description: BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL). Target: ATP Citrate Lyase. Smiles: COc1ccc(cc1NS(=O)(=O)c1cc(Cl)cc(Cl)c1O)-c1ccccc1. References: Li JJ, et al. 2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors. Bioorg Med Chem Lett. 2007...
| Schlagworte: | BMS 303141 |
| CAS | 943962-47-8 |
| MW: | 424.3 D |
ab 38,00 €
