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Pacritinib
Artikelnummer: TGM-T6020-100mg
Description: Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays). Target: FLT, Tyrosine Kinases, JAK. Smiles: C(CN1CCCC1)Oc1ccc2Nc3nccc(n3)-c3cccc(COC\C=C\COCc1c2)c3. References: Hart S, et al. Leukemia, 2011, 25(11), 1751-1759.
| Schlagworte: | SB1518 |
| Anwendung: | Targets Janus kinase 2 [EC:2.7.10.2] (JAK2) |
| CAS | 937272-79-2 |
| MW: | 472.58 D |
ab 34,00 €
Pacritinib
Artikelnummer: Cay16709-1
FMS-like tyrosine kinase 3 (FLT3) and Janus kinase 2 (JAK2) are tyrosine kinases that mediate cytokine signaling and are frequently mutated in cancers, particularly acute myeloid leukemia. Pacritinib is an inhibitor of both FLT3 and JAK2 (IC50s = 22 and 23 nM, respectively). It also blocks the activities of the FLT3...
| Schlagworte: | SB1518,... |
| Anwendung: | FLT3 / JAK2 inhibitor |
| CAS | 937272-79-2 |
| MW: | 472.6 D |
ab 61,00 €
