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OSI-027
Artikelnummer: Cay17379-1
The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin (Cay-13346)) and regulate different pathways. OSI-027 is an inhibitor of the catalytic site of...
| Schlagworte: | trans-4-[4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]-cyclohexanecarboxylic acid |
| Anwendung: | mTORC1 / mTORC2 inhibitor |
| CAS | 936890-98-1 |
| MW: | 406.4 D |
ab 50,00 €
OSI-027
Artikelnummer: LKT-O7332.1
OSI-027 is an inhibitor of mTORC1/2 that exhibits anticancer chemotherapeutic activity. In vitro, OSI0027 inhibits phosphorylation of downstream target Akt, inhibiting cell proliferation in breast cancer cells. OSI-027 also induces apoptosis in several lymphoid cell lines including mantle cell lymphoma, acute...
| Anwendung: | mTORC1/2 inhibitor |
| CAS | 936890-98-1 |
| MW: | 406.44 D |
ab 108,00 €
