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Ibrutinib
Artikelnummer: Cay16274-1
Bruton's tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating proliferation, survival, migration, and tissue homing of B-cells. Ibrutinib is an irreversible inhibitor of BTK (IC50 = 0.5 nM) that selectively blocks B cell activation,...
| Schlagworte: | Imbruvica, PCI 32765, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one |
| Anwendung: | BTK inhibitor |
| CAS | 936563-96-1 |
| MW: | 440.5 D |
ab 50,00 €
PCI-32765
Artikelnummer: LKT-P0932.1
PCI-32765 is an irreversible inhibitor of Bruton's tyrosine kinase (BTK), an enzyme that plays a significant role in B-cell receptor signaling and B-cell malignancies and autoimmune diseases such as x-linked agammaglobulinemia, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma. PCI-32765's inhibition of BTK...
| Schlagworte: | Ibrutinib |
| Anwendung: | Bruton's tyrosine kinase inhibitor |
| CAS | 936563-96-1 |
| MW: | 440.5 D |
ab 99,00 €
Ibrutinib
Artikelnummer: AG-CR1-3620-M025
White solid. Soluble in DMSO. Slightly soluble in ethanol (1mg/ml). Insoluble in water. Potent and highly selective Bruton's tyrosine kinase (BTK) inhibitor. Orally bioavailable and irreversible inhibitor of BTK (IC50 = 0.5 nM) with antineoplastic activity, Binds to and irreversibly inhibits BTK activity, preventing...
| Schlagworte: | PCI-32765 |
| Anwendung: | BTK inhibitor |
| CAS | 936563-96-1 |
| MW: | 440,5 D |
ab 88,00 €
Ibrutinib, Free Base
Artikelnummer: LC-I-3311_200mg
Solubility: Soluble in DMSO at 200 mg/mL, soluble in ethanol at 25 mg/mL with slight warming. Ibrutinib, also known as PCI-32765, is a selective and irreversible inhibitor of the enzyme Bruton's tyrosine kinase (BTK). It inhibited BTK potently, with an IC50 of 0.72 nM in enzymology assays and with an IC50 of 10 nM...
| Schlagworte: | CRA-032765, PCI-32765, PCI-32765-00 |
| Anwendung: | Selective, irreversible Bruton's tyrosine kinase (BTK) inhibitor |
| CAS | 936563-96-1 |
| MW: | 440.5 D |
ab 85,00 €
