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TG101348
Artikelnummer: Cay16289-1
TG101348 is a JAK2 inhibitor (IC50 = 3 nM for wild-type and JAK2V617F enzymes). It is 35-, 334-, and 135-fold selective for JAK2 over JAK1, JAK3, and tyrosine kinase 2 (TYK2), respectively. It is also selective for JAK2 over a panel of 34 kinases at 500 nM but does inhibit FMS-related tyrosine kinase 3 (FLT3) and...
| Schlagworte: | Fedratinib, SAR302503,... |
| Anwendung: | JAK2 inhibitor |
| CAS | 936091-26-8 |
| MW: | 524.7 D |
ab 85,00 €
TG101348
Artikelnummer: LKT-T2404.1
JAK2 inhibitor.
| Schlagworte: | SAR302503, Fedratinib |
| Anwendung: | JAK2 inhibitor |
| CAS | 936091-26-8 |
| MW: | 524.68 D |
ab 141,00 €
TG101348
Artikelnummer: SYN-1104-M001
Soluble in DMSO or ethanol. TG101348 inhibits JAK2(V617F) with an IC(50) of 3nM. It inhibits erythroid colony formation and also inhibits JAK2-driven STAT5 phosphorylation, cell proliferation and cell survival in JAK2(V617F) cells. Target: JAK , Kinase Group: PTK , Substrate: Tyrosine
| Schlagworte: | SAR-302503, TG-101348 |
| Anwendung: | JAK2 inhibitor |
| CAS | 936091-26-8 |
| MW: | 524,7 D |
ab 92,00 €
Fedratinib
Artikelnummer: TGM-T1995-100mg
Description: Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3. Target: JAK, FLT, Apoptosis, c-RET. Smiles: Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C. References: Wernig G, et al. Efficacy of TG101348, a...
| Schlagworte: | SAR 302503, TG-101348 |
| CAS | 936091-26-8 |
| MW: | 524.68 D |
ab 43,00 €
