Zu "934660-93-2" wurden 3 Artikel gefunden!
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Cobimetinib
Artikelnummer: Cay19563-1
Cobimetinib is a potent, orally available inhibitor of MEK1 (IC50 = 4.2 nM). It shows more than 100-fold selectivity for MEK when tested against a panel of more than 100 serine-threonine and tyrosine kinases. Cobimetinib induces differentiation and apoptosis in cancer cell lines and is more effective when combined...
| Schlagworte: | GDC-0973, RG-7420, XL518,... |
| Anwendung: | Antineoplastic, MEK inhibitor |
| CAS | 934660-93-2 |
| MW: | 531.3 D |
ab 66,00 €
GDC-0973
Artikelnummer: LKT-G124084.5
MEK1 inhibitor.
| Schlagworte: | GDC 0973, GDC0973, XL-518, XL 518, XL518, Cobimetinib, RG-7420, RG 7420, RG7420 |
| Anwendung: | Mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitor |
| CAS | 934660-93-2 |
| MW: | 531.32 D |
ab 108,00 €
Cobimetinib, Free Base
Artikelnummer: LC-C-1100_100mg
Soluble in DMSO. Cobimetinib demonstrated a sustained tumor pharmacodynamic response due to longer residence times in tumor tissue than in plasma in mice. Following single doses, cobimetinib inhibited pERK in tumors with IC50 values of 780 nM in WM-266-4 and 520 nM in A375 xenograft mice. Following multiple doses,...
| Schlagworte: | GDC0973, RG7420, XL518 |
| Anwendung: | Antineoplastic, Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor |
| CAS | 934660-93-2 |
| MW: | 531.31 D |
ab 87,00 €
