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Osilodrostat
Artikelnummer: TGM-T4277-10mg
Description: Osilodrostat (LCI699) (LCI699) is an effective inhibitor of human 11beta-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM). Target: Others, Hydroxylase, Glucocorticoid Receptor. Smiles: Fc1cc(ccc1[C@H]1CCc2cncn12)C#N. References: Li L, et al. Osilodrostat (LCI699), a potent...
| Schlagworte: | LCI699 |
| Anwendung: | Targets steroid 11beta-monooxygenase / corticosterone 18-monooxygenase (CYP11B2) |
| CAS | 928134-65-0 |
| MW: | 227.24 D |
ab 43,00 €
Osilodrostat
Artikelnummer: Cay33928-10
Osilodrostat is an inhibitor of aldosterone synthase (IC50 = 0.7 nM for the recombinant human enzyme). It is selective for human aldosterone synthase over rat aldosterone synthase (IC50 = 160 nM). Osilodrostat inhibits increases in plasma aldosterone levels induced by angiotensin II or adrenocorticotropic hormone...
| Schlagworte: | LCI699, 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluoro-benzonitrile |
| Anwendung: | Aldosterone synthase inhibitor |
| CAS | 928134-65-0 |
| MW: | 227.2 D |
ab 119,00 €
