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HA-14-1
Artikelnummer: Cay14876-5
HA-14-1 is a small molecule that binds the surface pocket of Bcl-2 proteins (IC50 = ~ 9 µM) and induces apoptosis by interfering with its interaction with the Bak peptide and activating Apaf-1 and caspase-9 and -3. It can also bind to the antiapoptotic Bcl-2 proteins Bcl-xl and Bcl-W. HA-14-1 has been shown to...
| Schlagworte: | (alphaR,4R)-rel-2-amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid, ethyl ester |
| Anwendung: | Apoptosis inducer |
| CAS | 927635-64-1 |
| MW: | 409.2 D |
ab 51,00 €
HA-14-1
Artikelnummer: TGM-T84388-10mg
Description: HA-14-1, a small molecule, binds the surface pocket of Bcl-2 proteins (IC50= ~ 9 µM), including Bcl-xl and Bcl-W, and disrupts their interaction with the Bak peptide. This action induces apoptosis by activating Apaf-1 and caspase-9 and -3. Additionally, HA-14-1 effectively induces apoptosis in human...
| Anwendung: | Apoptosis inducer |
| CAS | 927635-64-1 |
| MW: | 409.2 D |
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