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AS1517499
Artikelnummer: Cay29071-1
AS1517499 is a STAT6 inhibitor (IC50 = 21 nM in a reporter assay). It inhibits IL-4-induced Th2 differentiation (IC50 = 2.3 nM), but not IL-12-induced Th1 differentiation, of mouse spleen T cells. AS1517499 (10 mg/kg) inhibits bronchial smooth muscle hyperresponsiveness and IL-13 production in ovalbumin-sensitized...
| Schlagworte: | 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]amino]-4-[(phenylmethyl)amino]-5-pyrimidinecarboxamide |
| Anwendung: | STAT6 inhibitor |
| CAS | 919486-40-1 |
| MW: | 397.9 D |
ab 51,00 €
AS1517499
Artikelnummer: TGM-T4476-100mg
Description: AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM. Target: STAT. Smiles: NC(=O)c1cnc(NCCc2ccc(O)c(Cl)c2)nc1NCc1ccccc1. References: Nagashima S, et al. Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg Med Chem....
| Anwendung: | STAT6 inhibitor |
| CAS | 919486-40-1 |
| MW: | 397.86 D |
ab 33,00 €
AS1517499
Artikelnummer: BPS-82693-1
AS1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC50 of 21 nM.1
| Schlagworte: | STAT6 inhibitor, |
| Anwendung: | Cell signaling pathway studies |
| CAS | 919486-40-1 |
| MW: | 397,86 D |
ab 389,00 €
