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Evofosfamide
Artikelnummer: TGM-T3615-100mg
Description: Evofosfamide (TH-302) is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM) conjugated with 2-nitroimidazole, possessing potential antineoplastic activity. Under hypoxic conditions, typical of hypoxic tumors, the 2-nitroimidazole moiety is reduced, releasing the...
| Schlagworte: | TH-302 |
| Anwendung: | Antineoplastic, Alkylating agent |
| CAS | 918633-87-1 |
| MW: | 449.04 D |
ab 48,00 €
TH-302
Artikelnummer: Cay22195-1
TH-302 is a hypoxia-activated prodrug and DNA alkylating agent with anticancer activity. It is selectively cytotoxic to H460 human non-small cell lung cancer (NSCLC) cells grown under hypoxic over normoxic conditions (IC50s = 0.019 and 5.1 µM, respectively). Under hypoxic conditions, TH-302 undergoes a one-electron...
| Schlagworte: | Evofosfamide, N,N'-bis(2-bromoethyl)-phosphorodiamidic acid, (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester |
| Anwendung: | Antineoplastic, alkylating agent, prodrug |
| CAS | 918633-87-1 |
| MW: | 449 D |
ab 55,00 €
