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YS-121
Artikelnummer: Cay13665-1
Microsomal prostaglandin E2 synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever, and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. YS-121 is a dual inhibitor of...
| Schlagworte: | 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-octanoic acid |
| Anwendung: | mPGES-1/5-LO inhibitor |
| CAS | 916482-17-2 |
| MW: | 408 D |
ab 83,00 €
YS-121
Artikelnummer: TGM-T22172-10mg
Description: YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1, IC50=3.4 µM) and 5-lipoxygenase (5-LOX, IC50=6.5 µM). YS121 dose-dependently reduces the production of PGE2 with EC50=12 µM in IL-1beta-stimulated A549 cells [1]. Target: Others. Smiles:...
| Anwendung: | mPGES-1/5-LO inhibitor |
| CAS | 916482-17-2 |
| MW: | 407.96 D |
ab 185,00 €
