Zu "916047-16-0" wurden 2 Artikel gefunden!
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CAY10595
Artikelnummer: TGM-T10691-100mg
Description: CAY10595 is an antagonist of the CRTh2 (DP2) receptor with a Ki of 10 nM. Target: GPR. Smiles: O=C1C2(C=3C(N1CC(O)=O)=CC=C(Cl)C3)C(=O)N(CC4=C(F)C=CC(Cl)=C4)C(=O)C2. References: Crosignani S, et al. Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists...
| CAS | 916047-16-0 |
| MW: | 451.23 D |
ab 46,00 €
CAY10595
Artikelnummer: Cay10012553-1
The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10595, as a racemic mixture, is...
| Schlagworte: | 5-chloro-1'-[5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxo-spiro[3H-indole-3,3'pyrrolidine]-1(2H)-acetic acid |
| Anwendung: | CRTH2receptor antagonist, DP2 receptor antagonist |
| CAS | 916047-16-0 |
| MW: | 451.2 D |
ab 91,00 €
