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Onalespib
Artikelnummer: Cay10655-1
Onalespib is a selective inhibitor of Hsp90 (IC50 = 18 nM). It induces the degradation of specific Hsp90 client proteins, including mutant EGFR, for up to seven days in tumor cell lines in vitro and up to three days in vivo. Onalespib is retained in tumor xenografts and is efficacious in a range of xenograft...
| Schlagworte: | AT-13387, [1,3-dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]-methanone |
| Anwendung: | Antineoplastic, Hsp90 inhibitor |
| CAS | 912999-49-6 |
| MW: | 409.5 D |
ab 67,00 €
Onalespib
Artikelnummer: TGM-T6284-100mg
Description: Onalespib (AT13387) is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins...
| Schlagworte: | AT13387 , Onalespib (AT13387) |
| Anwendung: | Antineoplastic, Hsp 90 inhibitor |
| CAS | 912999-49-6 |
| MW: | 409.52 D |
ab 37,00 €
