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MLN4924
Artikelnummer: Cay15217-1
NEDD8 is an ubiquitin-like protein whose activity is required to activate cullin-RING ubiquitin E3 ligases (CRLs) responsible for the ubiquitination and proteasome-dependent turnover of certain substrates with roles relevant to cellular processes important for cancer cell survival. Neddylation of CRLs is initiated...
| Schlagworte: | Pevonedistat, sulfamic acid,... |
| Anwendung: | Adenosine 5'-monophosphate analog, NAE inhibitor |
| CAS | 905579-51-3 |
| MW: | 443.5 D |
ab 79,00 €
MLN-4924
Artikelnummer: LKT-M4454.1
MLN4924 acts as a Nedd8-activating enzyme inhibitor, blocking proteasomal cullin protein neddylation by Cullin-RING E3 ubiquitin ligases. As a result, these proteins accumulate, inducing cell cycle arrest, senescence, autophagy, and/or apoptosis in cellular and animal models. This compound's inhibition of...
| Anwendung: | NEDD activating enzyme (NAE) inhibitor |
| CAS | 905579-51-3 |
| MW: | 443.16 D |
ab 224,00 €
![MLN4924 [NAE Inhibitor]](https://www.biomol.com/media/image/12/6c/14/AG-CR1-3703-M005_200x200.png "MLN4924 [NAE Inhibitor]")
MLN4924 [NAE Inhibitor]
Artikelnummer: AG-CR1-3703-M005
White solid. Soluble in DMSO (30mg/ml), ethanol (10mg/ml) or DMF (20mg/ml). Insoluble in water. Chemical. CAS: 905579-51-3. Formula: C21H25N5O4S . H2O. MW: 443.5 . 18.0. Adenosine 5'-monophosphate (AMP) analog. Potent, selective and cell permeable inhibitor of Nedd8 E1 Activating Enzyme (NAE) (IC50=4.7nM). NEDD8 is...
| Schlagworte: | Pevonedistat, Nedd8 E1 Activating Enzyme Inhibitor, TAK924 |
| CAS | 905579-51-3 |
| MW: | 461,5 D |
ab 132,00 €
MLN4924 Solution
Artikelnummer: AG-CS1-0103-M001
Liquid. Potent, selective and cell-permeable inhibitor of Nedd8 E1 Activating Enzyme (NAE), By inhibiting the Neddylation pathway this molecule disrupts cullin-RING ligase activity, leading to inhibition of proliferation or apoptotic death of various human tumor cells through the deregulation of S-phase DNA synthesis.
| Schlagworte: | Pevonedistat, Nedd8 E1 Activating Enzyme Inhibitor |
| Anwendung: | Potent, selective, cell-permeable Nedd8 E1 activating enzyme inhibitor |
| CAS | 905579-51-3 |
| MW: | 443,5 D |
264,00 €
Pevonedistat
Artikelnummer: TGM-T6332-100mg
Description: Pevonedistat (MLN4924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50=4.7 nM) with therapeutic potential for myelodysplastic syndromes (MDS) and antitumor activity. Target: NEDD8, E1/E2/E3 Enzyme. Smiles: NS(=O)(=O)OC[C@@H]1CC(C[C@@H]1O)n1ccc2c(NC3CCc4ccccc34)ncnc12....
| Schlagworte: | MLN4924 |
| Anwendung: | Targets NEDD8-activating enzyme E1 regulatory subunit (NAE1, APPBP1) |
| CAS | 905579-51-3 |
| MW: | 443.52 D |
ab 46,00 €
