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AS-252424
Artikelnummer: Cay10009052-5
AS-252424 is a potent inhibitor of phosphatidylinositol-3-kinase PI3K with selectivity for the gamma isoform. It inhibits human recombinant PI3Kgamma, alpha, beta, and delta with IC50 values of 30, 940, 20,000 and 20,000 nM, respectively. AS-252424 also inhibits C5a-mediated phosphorylation of Akt in RAW 264.7...
| Schlagworte: | 5-[5-(4-fluoro-2-hydroxy-phenyl)-furan-2-ylmethylene]-thiazolidine-2,4-dione |
| Anwendung: | PI3K inhibitor |
| CAS | 900515-16-4 |
| MW: | 305.3 D |
ab 58,00 €
AS-252424
Artikelnummer: LKT-A7200.1
AS-252424 is an inhibitor of p110 PI3K that exhibits anti-inflammatory activity. In animal models of peritoneal inflammation, AS-252424 decreases leukocyte recruitment. In vascular smooth muscle cells, AS-252424 decreases endothelin A receptor-mediated activity of transient receptor potential canonical 1/5/6...
| Anwendung: | PI3K p110 inhibitor |
| CAS | 900515-16-4 |
| MW: | 305.28 D |
ab 82,00 €
AS-252424
Artikelnummer: SYN-1009-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. AS-252424 is a potent and selective PI3K inhibitor. It inhibits human recombinant PI3K alpha, beta, gamma and delta with IC(50) values of 30, 940, 20.000, and 20.000nM respectively. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | AS252424 |
| Anwendung: | PI3K inhibitor |
| CAS | 900515-16-4 |
| MW: | 305,3 D |
ab 100,00 €
AS-252424
Artikelnummer: TGM-T6208-100mg
Description: AS-252424 is a potent and selective inhibitor of PI3Kgamma with an IC50 of 33 nM and demonstrates over 10-fold selectivity for PI3Kgamma versus PI3Kalpha. Target: Casein Kinase, PI3K. Smiles: Oc1cc(F)ccc1-c1ccc(\C=C2/SC(=O)NC2=O)o1. References: Pomel V, et al, J Med Chem, 2006, 49(13), 3857-3871.
| Anwendung: | PI3K inhibitor |
| CAS | 900515-16-4 |
| MW: | 305.28 D |
ab 32,00 €
