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SCH 900776
Artikelnummer: Cay18131-500
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. SCH 900776 is a functionally selective inhibitor of Chk1 (Kd = 2 nM, IC50 = 3 nM). In comparison, 18-fold and 500-fold higher concentrations of this compound are required to inhibit CDK2 and Chk2. At 5-50 mg/kg,...
| Schlagworte: | MK-8776, 6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinyl-pyrazolo[1,5-a]pyrimidin-7-amine |
| Anwendung: | Chk1 inhibitor |
| CAS | 891494-63-6 |
| MW: | 376.3 D |
ab 62,00 €
SCH-900776
Artikelnummer: SYN-1173-M001
Soluble in DMSO or ethanol. SCH900776 is a selective Chk1 inhibitor with an IC(50) of 3nM. It shows 50-fold selectivity for Chk1 versus Chk2. Target: Chk1 , Kinase Group: CAMK , Substrate: Serine-Threonine
| Schlagworte: | MK-8776 |
| Anwendung: | Chk1 inhibitor |
| CAS | 891494-63-6 |
| MW: | 376,3 D |
ab 162,00 €
SCH-900776
Artikelnummer: LKT-S0928.1
SCH-900776 is an inhibitor of CHK1 that exhibits anticancer activity. SCH-900776 may also exhibit chemotherapeutic benefit as it is currently in clinical trials as a potential co-administered treatment for cancer. With other chemotherapeutics, SCH-900776 induces ds DNA strand breaks and cell death.
| Anwendung: | Chk1 inhibitor |
| CAS | 891494-63-6 |
| MW: | 376.25 D |
ab 248,00 €
SCH900776
Artikelnummer: TGM-T2517-100mg
Description: SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Target: Chk, CDK. Smiles: Cn1cc(cn1)-c1cnn2c(N)c(Br)c(nc12)[C@@H]1CCCNC1. References: Guzi TJ, et al. Mol Cancer Ther, 2011, 10(4), 591-602.
| Schlagworte: | MK-8776, MK 8776 |
| CAS | 891494-63-6 |
| MW: | 376.25 D |
ab 48,00 €
