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Supinoxin
Artikelnummer: TGM-T16961-100mg
Description: Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase and a potent first-in-class anti-cancer agent, inducing cell apoptosis and inhibiting the growth of TNBC cancer cell lines (IC50s: 10 nM - 20 nM). Target: Apoptosis, DNA/RNA Synthesis. Smiles:...
| Schlagworte: | RX-5902 |
| Anwendung: | Tyr593-phosphorylated DDX5 inhibitor |
| CAS | 888478-45-3 |
| MW: | 441.46 D |
ab 114,00 €
Supinoxin
Artikelnummer: Cay36573-1
Supinoxin is an inhibitor of Y593-phosphorylated DEAD-box helicase 5 (DDX5). It binds to Y593-phosphorylated DDX5 (Kd = ~19 nM), but does not interact with unphosphorylated DDX5, and selectively inhibits beta-catenin-dependent ATPase activity over RNA-dependent ATPase activity at 0.2 µM. Supinoxin induces apoptosis...
| Schlagworte: | RX-5902, 4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxy-2-quinoxalinyl)-1-piperazinecarboxamide |
| Anwendung: | Tyr593-phosphorylated DDX5 inhibitor |
| CAS | 888478-45-3 |
| MW: | 441.5 D |
ab 87,00 €
