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GW 2580
Artikelnummer: Cay15411-25
cFMS kinase is the cellular homolog of the v-FMS oncogene product of the Susan McDonough strain of the feline sarcoma virus. It can autophosphorlyate colony-stimulating factor (CSF-1), which promotes the survival, proliferation, and differentiation of mononuclear phagocytes. GW 2580 selectively inhibits cFMS kinase...
| Schlagworte: | 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine |
| Anwendung: | CSF1R kinase inhibitor |
| CAS | 870483-87-7 |
| MW: | 366.4 D |
ab 56,00 €
![GW2580, Free Base (5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine)](https://www.biomol.com/media/image/a0/f3/28/G9951-25-100_200x200.jpg "GW2580, Free Base (5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine)")
GW2580, Free Base...
Artikelnummer: G9951-25.100
GW2580 is a small-molecule inhibitor of cFMS kinase, at 60nM it inhibited human cFMS kinase completely in vitro and was inactive against 26 other kinases. GW2580 inhibited lipopolysaccharide (LPS)-induced TNF production in mice, but not LPS-induced TNF production in freshly isolated human monocytes and mouse...
| CAS | 870483-87-7 |
| MW: | 366.41 |
375,00 €
GW2580
Artikelnummer: TGM-T2659-100mg
Description: GW2580 (SC-203877) is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS. Target: c-Fms. Smiles: COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1. References: Conway JG, et al. Proc Natl Acad Sci U S A, 2005, 102(44), 16078-16083.
| Schlagworte: | GW 2580, SC-203877 |
| CAS | 870483-87-7 |
| MW: | 366.41 D |
ab 41,00 €
