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A-841720
Artikelnummer: Cay21807-1
A-841720 is a noncompetitive antagonist of the group 1 metabotropic glutamate receptor mGluR1 with an IC50 value of 10.7 nM for inhibition of L-glutamate-induced calcium release in 1321 N1 cells. It is selective for mGluR1 over mGluR5 (IC50 = 343 nM) as well as mGluR2, mGluR4, and mGluR7, where it does not inhibit...
| Schlagworte: | 9-(dimethylamino)-3-(hexahydro-1H-azepin-1-yl)-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one |
| Anwendung: | Noncompetitive mGluR1 antagonist |
| CAS | 869802-58-4 |
| MW: | 343.5 D |
ab 49,00 €
A 841720
Artikelnummer: TGM-T21848-1mg
Description: A-841720 is a potent, selective, and non-competitive antagonist of the mGlu1 receptor, exhibiting an IC 50 value of 10 nM specifically for the human mGlu1 receptor. It demonstrates a 34-fold greater selectivity for mGlu1 over mGlu5 (IC 50 of 342 nM), with negligible activity across a spectrum of other...
| Anwendung: | Noncompetitive mGluR1 antagonist |
| CAS | 869802-58-4 |
| MW: | 343.45 D |
ab 106,00 €
