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Quarfloxin
Artikelnummer: TGM-T16703-100mg
Description: Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA template. Target: DNA/RNA Synthesis....
| Schlagworte: | CX-3543 |
| Anwendung: | Targets DNA topoisomerase II [EC:5.6.2.2] (TOP2) |
| CAS | 865311-47-3 |
| MW: | 604.67 D |
ab 120,00 €
Quarfloxin
Artikelnummer: Cay36552-1
Quarfloxin is an inhibitor of RNA polymerase I-mediated transcription. It binds to G-quadruplex DNA and inhibits the interaction between ribosomal DNA G-quadruplexes and nucleolin, a nucleolar protein required for RNA polymerase I-mediated transcription. Quarfloxin (10 µM) induces nucleolin mislocalization from the...
| Schlagworte: | CX-3543, Itarnafloxin, Quarfloxacin,... |
| Anwendung: | RNA polymerase I-mediated transcription inhibitor, antineoplastic, topoisomerase II inhibitor |
| CAS | 865311-47-3 |
| MW: | 604.7 D |
ab 83,00 €
