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NEU
BMS 690514
Artikelnummer: Cay44552-1
BMS 690514 is a pan-inhibitor of HER and VEGFR family kinases (IC50s = 5, 19, 60, 50, 50, and 25 nM for EGFR, HER2, HER4, VEGFR1, VEGFR2, and VEGFR3, respectively). It is selective for these kinases over 11 additional kinases but also inhibits FMS-related tyrosine kinase 3 (FLT3), calcium/calmodulin-dependent...
| Schlagworte: | (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]-3-piperidinol |
| Anwendung: | HER / VEGFR family kinase pan-inhibitor |
| CAS | 859853-30-8 |
| MW: | 368.44 D |
ab 57,00 €
BMS-690514
Artikelnummer: TGM-T14677-2mg
Description: BMS-690514 is a potent, orally active inhibitor of EGFR and VEGFR, with IC50 values of 5 nM for EGFR, 20 nM for HER 2, and 60 nM for HER 4. Target: VEGFR, EGFR, HER. Smiles: COc1cccc(Nc2ncnn3ccc(CN4CC[C@@H](N)[C@H](O)C4)c23)c1. References: Wong TW, et al. Antitumor and antiangiogenic activities of...
| CAS | 859853-30-8 |
| MW: | 368.43 D |
141,00 €
