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AUZ 454
Artikelnummer: TGM-T6866-100mg
Description: AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd values of 50 nM for CDK2(WT), 18.6 nM for CDK2(C118L), 15.4 nM for CDK2(A144C), and 9.7 nM for CDK2(C118L/A144C). Target: CDK. Smiles: CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1. References: Meng T G, Lei W L, Li J, et al. Degradation...
| Schlagworte: | K03861 |
| CAS | 853299-07-7 |
| MW: | 501.5 D |
ab 41,00 €
K03861
Artikelnummer: Cay19921-10
K03861 is an inhibitor of cyclin-dependent kinase 2 (Cdk2). It binds to wild-type Cdk2, Cdk2C118L, Cdk2A144C, and Cdk2C118L/A144C (Kds = 50, 18.6, 15.4, and 9.7 nM, respectively). K03861 selectively inhibits the proliferation of IL-3-stimulated Ba/F3 cells expressing an FMS-related tyrosine kinase 3 bearing...
| Schlagworte: | AUZ454, N-[4-[(2-amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-urea |
| Anwendung: | Cdk2 inhibitor |
| CAS | 853299-07-7 |
| MW: | 501.5 D |
ab 107,00 €
