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SSR 128129E
Artikelnummer: Cay22128-1
SSR 128129E is a potent inhibitor of the FGF receptor (FGFR, IC50 = 1.9 nM). It reduces FGF2-induced endothelial cell proliferation and migration (IC50s = 31 and 15.2 nM, respectively), as well as lamellipodia formation in vitro. SSR 128129E also reduces proliferation of PAE cells expressing FGFR1, mPanc02 cells...
| Schlagworte: | 2-amino-5-[(1-methoxy-2-methyl-3-indolizinyl)carbonyl]-benzoic acid, monosodium salt |
| Anwendung: | FGFR Inhibitor |
| CAS | 848318-25-2 |
| MW: | 346.3 D |
ab 52,00 €
SSR128129E
Artikelnummer: TGM-T6082-100mg
Description: SSR128129E (SSR) is an allosteric and orally-active FGFR1 inhibitor (IC50: 1.9 µM), but not affecting other related RTKs. Target: FGFR. Smiles: [Na+].COc1c(C)c(C(=O)c2ccc(N)c(c2)C([O-])=O)n2ccccc12. References: Bono F, et al. Cancer Cell. 2013, 23(4), 477-488.
| Schlagworte: | SSR |
| Anwendung: | FGFR Inhibitor |
| CAS | 848318-25-2 |
| MW: | 346.31 D |
ab 33,00 €
