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R406
Artikelnummer: Cay11422-1
R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcepsilonRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 µM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce...
| Schlagworte: | 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one |
| Anwendung: | Potent ATP-competitive Syk inhibitor |
| CAS | 841290-80-0 |
| MW: | 470.5 D |
ab 94,00 €
R406
Artikelnummer: SYN-1121-M001
Soluble in DMSO or ethanol. R406 is a strong Syk inhibitor with an IC(50) of 41nM. It inhibits Syk but not Lyn. It shows 5-fold less potency to Flt3. Target: Syk , Kinase Group: PTK , Substrate: Tyrosine
| Schlagworte: | R-406 |
| Anwendung: | Syk inhibitor |
| CAS | 841290-80-0 |
| MW: | 470,5 D |
ab 154,00 €
R406 free base
Artikelnummer: TGM-T2467-100mg
Description: R406 free base (R406 (free base)) is a potent Syk inhibitor. Target: Syk, Apoptosis, FLT. Smiles: COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC. References: Braselmann S, et al. J Pharmacol Exp Ther, 2006, 319(3), 998-1008.
| Schlagworte: | R406 (free base) |
| Anwendung: | Potent ATP-competitive Syk inhibitor |
| CAS | 841290-80-0 |
| MW: | 470.45 D |
ab 40,00 €
