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GNF-7
Artikelnummer: Cay19918-1
GNF-7 is a multi-kinase inhibitor (IC50s = 25, 8, 61, 122, 136, and 133 nM for ACK1, GCK, Bcr-AblT315I, Bcr-AblE255V, Bcr-AblG250E, and c-Abl, respectively). It also inhibits several additional kinases in a panel by greater than 50% when used at a concentration of 10 µM. GNF-7 inhibits the growth of Ba/F3 cells...
| Schlagworte: | N-[3-[1,4-dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trif... |
| Anwendung: | Ack1 / GCK inhibitor |
| CAS | 839706-07-9 |
| MW: | 547.5 D |
ab 49,00 €
GNF-7
Artikelnummer: TGM-T3196-100mg
Description: GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively. Target: AChR, Bcr-Abl, ACK. Smiles: CN1C(=O)N(Cc2cnc(Nc3ccc(C)nc3)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C. References: Choi HG, et al. J Med Chem. 2010, 53(15), 5439-5448.
| Schlagworte: | GNF7 |
| Anwendung: | Ack1 / GCK inhibitor |
| CAS | 839706-07-9 |
| MW: | 547.53 D |
ab 36,00 €
