Zu "64048-12-0" wurden 2 Artikel gefunden!
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GANT 58
Artikelnummer: TGM-T15370-100mg
Description: GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 µM). Target: Hedgehog/Smoothened. Smiles: c1cc(ccn1)-c1sc(c(c1-c1ccncc1)-c1ccncc1)-c1ccncc1. References: Lauth M, et al. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule...
| Schlagworte: | NSC 75503 |
| Anwendung: | GLI antagonist |
| CAS | 64048-12-0 |
| MW: | 392.48 D |
ab 42,00 €
GANT 58
Artikelnummer: Cay14193-5
Hedgehog (hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened (Smo). In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain...
| Schlagworte: | NSC 75503, 4,4',4'',4'''-(2,3,4,5-thiophenetetrayl)tetrakis-pyridine |
| Anwendung: | GLI antagonist |
| CAS | 64048-12-0 |
| MW: | 392.5 D |
ab 99,00 €
