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Binimetinib
Artikelnummer: Cay16996-5
Binimetinib is a MEK1 and MEK2 inhibitor (IC50s = 1.8 and 0.92 nM, respectively). It is selective for MEK1/2 over a panel of RAF/MEK/ERK pathway kinases at 10 µM. Binimetinib reduces cell growth in HT-29, COLO 205, and LoVo colorectal cancer cell lines (IC50s = 0.48, 0.52, and 2.2 nM, respectively). It reduces tumor...
| Schlagworte: | ARRY-438162, MEK162, 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide |
| Anwendung: | MEK1/2 inhibitor |
| CAS | 606143-89-9 |
| MW: | 441.2 D |
ab 85,00 €
ARRY-162
Artikelnummer: LKT-A6971.100
MEK162 (ARRY-162) is an oral, highly selective MEK inhibitor. In preclinical studies, MEK162 showed significant antitumor activities in cell lines and animal models.
| Schlagworte: | ARRY162, MEK162, MEK-162,... |
| Anwendung: | MEK inhibitor |
| CAS | 606143-89-9 |
| MW: | 441.23 D |
ab 94,00 €
Binimetinib
Artikelnummer: TGM-T2508-1mL
Description: Binimetinib (ARRY-162) (MEK162, ARRY-162, ARRY-438162) is an orally available inhibitor of MEK1/2 (IC50: 12 nM) in a cell-free assay. Target: MEK, Autophagy. Smiles: Cn1cnc2c(F)c(Nc3ccc(Br)cc3F)c(cc12)C(=O)NOCCO. References: J Pheneger, et al. 2006, ACR Annual Scientific Meeting. Abst 794.
| Schlagworte: | MEK162, ARRY-162, ARRY-438162 |
| Anwendung: | Targets mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] (MAP2K1, MEK1) |
| CAS | 606143-89-9 |
| MW: | 441.23 D |
ab 34,00 €
