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R112
Artikelnummer: TGM-T3185-100mg
Description: R112 is an ATP-competitive inhibitor of Syk kinase. Ki=6 nM,IC50=226 nM. Target: Syk. Smiles: Oc1cccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)c1. References: Rossi AB, et al. J Allergy Clin Immunol. 2006 Sep,118(3):749-55.
| Schlagworte: | (E)-Elafibranor |
| Anwendung: | Syk inhibitor |
| CAS | 575474-82-7 |
| MW: | 312.3 D |
ab 34,00 €
R112
Artikelnummer: Cay22929-1
R112 is an inhibitor of spleen tyrosine kinase (Syk, IC50 = 226 nM in cultured human mast cells) that acts in an ATP-competitive and reversible manner (Ki = 96 nM). It inhibits mast cell and basophil degranulation induced by anti-IgE cross-linking (EC50s = 353 and 280 nM, respectively). It also inhibits basophil...
| Schlagworte: | 3,3'-[(5-fluoro-2,4-pyrimidinediyl)diimino]bis-phenol |
| Anwendung: | Syk inhibitor |
| CAS | 575474-82-7 |
| MW: | 312.3 D |
ab 35,00 €
