Zu "475110-96-4" wurden 5 Artikel gefunden!
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ZSTK474
Artikelnummer: Cay17381-5
ZSTK474 is a triazine derivative that acts as an inhibitor of class I phosphatidylinositol 3-kinase (PI3K) isoforms (IC50s = 17, 53, and 6 nM for p110beta, -gamma, and -delta, respectively). It is selective for PI3K, as it has negligible activity against 139 other kinases when tested at 30 µM. ZSTK474 is orally...
| Schlagworte: | 2-(difluoromethyl)-1-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-1H-benzimidazole |
| Anwendung: | PI3K class I inhibitor |
| CAS | 475110-96-4 |
| MW: | 417.4 D |
ab 73,00 €
ZSTK474
Artikelnummer: LKT-Z7477.5
ZSTK474 is an inhibitor of PI3K that exhibits anticancer chemotherapeutic, anti-inflammatory, and anti-arthritis activities. ZSTK474 suppresses expression of matrix metalloproteinases (MMPs), VEGF, and HIF-1 , inhibiting migration, invasion, and adhesive capability of prostate cancer cells. ZSTK474 also induces G1...
| Anwendung: | PI3K inhibitor |
| CAS | 475110-96-4 |
| MW: | 417.41 D |
ab 72,00 €
ZSTK474, Free Base...
Artikelnummer: Z0886-50.50
ZSTK474, a novel s-triazine derivative, binds to the ATP-binding site of Class I phosphatidylinositol 3-kinases (PI3K) and inhibits PI3K activity. ZSTK474 has strong antitumor activities against human cancer xenografts (A549, PC-3 and WiDr) when administered orally to mice. Furthermore, ZSTK474 did not show...
| CAS | 475110-96-4 |
| MW: | 417.41 |
228,00 €
ZSTK474
Artikelnummer: SYN-1099-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. ZSTK474 inhibits all four PI3K isoforms in an ATP-competitive manner. IC(50) is approximately 37nM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
| Schlagworte: | ZSTK-474 |
| Anwendung: | PI3K inhibitor |
| CAS | 475110-96-4 |
| MW: | 417,4 D |
ab 77,00 €
ZSTK474
Artikelnummer: TGM-T6168-100mg
Description: PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Target: PI3K, Autophagy. Smiles: FC(F)c1nc2ccccc2n1-c1nc(nc(n1)N1CCOCC1)N1CCOCC1. References: Yaguchi S, et al. J Natl Cancer...
| Anwendung: | PI3K class I inhibitor |
| CAS | 475110-96-4 |
| MW: | 417.41 D |
ab 31,00 €
