Zu "469-59-0" wurden 2 Artikel gefunden!
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Jervine
Artikelnummer: TGM-T3363-100mg
Description: The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated...
| Schlagworte: | 11-Ketocyclopamine, Iervin, Jerwiny |
| Anwendung: | Sonic hedgehog pathway inhibitor, birth defect inducer |
| CAS | 469-59-0 |
| MW: | 425.6 D |
ab 63,00 €
Jervine
Artikelnummer: Cay11723-1
Jervine is a naturally occurring teratogenic alkaloid that inhibits the sonic hedgehog pathway (IC50s = 500-700 nM) in vitro. It induces a variety of birth defects in vivo, including holoprosencephaly, cyclopia, cebocephaly, exencephaly, and microphthalmia in rat, chicken, and sheep. Jervine also reduces lipid...
| Schlagworte: | NSC 23898, NSC 7520,... |
| Anwendung: | Sonic hedgehog pathway inhibitor, birth defect inducer |
| CAS | 469-59-0 |
| MW: | 425.6 D |
ab 44,00 €
