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SJ 172550
Artikelnummer: Cay19999-1
SJ 172550 is an inhibitor of MDMX that disrupts MDMX-p53 peptide interaction with an EC50 value of 4.3 µM. It forms a covalent, but reversible, cysteine adduct in the MDMX p53-binding domain, locking MDMX into a conformation that prevents binding to p53. SJ 172550 induces apoptosis, increases p53 target gene...
| Schlagworte: | MDMX Inhibitor II,... |
| Anwendung: | MDM4 inhibitor |
| CAS | 431979-47-4 |
| MW: | 428.9 D |
ab 73,00 €
SJ-172550
Artikelnummer: TGM-T16888-100mg
Description: SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 µM). Target: Mdm2, E1/E2/E3 Enzyme. Smiles: CCOc1cc(\C=C2/C(C)=NN(C2=O)c2ccccc2)cc(Cl)c1OCC(=O)OC. References: Reed D, et al. Identification and characterization of the first small molecule inhibitor of MDMX. J Biol Chem. 2010 Apr...
| Anwendung: | MDM4 inhibitor |
| CAS | 431979-47-4 |
| MW: | 428.87 D |
ab 36,00 €
