Zu "405554-55-4" wurden 3 Artikel gefunden!
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SB-590885
Artikelnummer: Cay16643-1
B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. Mutations of B-Raf, particularly at Val600, are common in melanomas and melanocytic nevi. SB-590885 is a potent inhibitor of B-Raf (Kd = 0.3 nM). It less effectively inhibits c-Raf (Ki =...
| Schlagworte: | 5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime |
| Anwendung: | Potent B-Raf inhibitor |
| CAS | 405554-55-4 |
| MW: | 453.5 D |
ab 66,00 €
SB-590885
Artikelnummer: LKT-S0459.1
Potent B-Raf inhibitor, selective for B-Raf against 46 other kinases. Decreases anchorage-independent growth of melanoma cell lines. Inhibits ERK phosphorylation and proliferation in tumor cells expressing B-Raf.
| Schlagworte: | SB590885, (E)-5-(2-(4-(2-(dimethylamino)ethoxy)phenyl)-4-(pyridin-4-yl)-1H-imidazol-5-yl)-2,3-dihydroinden-1-one oxime |
| Anwendung: | B-Raf inhibitor |
| CAS | 405554-55-4 |
| MW: | 453.54 D |
ab 115,00 €
SB-590885
Artikelnummer: SYN-1077-M001
Soluble in DMSO or ethanol. SB-590885 is a novel, potent and selective small molecule inhibitor of B-Raf kinase, with a Ki of 0.16nM. It shows an 11-fold greater selectivity for B-Raf over c-Raf. It was used to address the dependence of MAPK signalling and tumor cell growth on B-Raf kinase activity. Target: ARaf -...
| Schlagworte: | SB-590885 |
| Anwendung: | BRAF inhibitor |
| CAS | 405554-55-4 |
| MW: | 453,5 D |
ab 106,00 €
