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CHIR-124
Artikelnummer: TGM-T6350-100mg
Description: CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4. Target: GSK-3, Apoptosis, FLT, Chk, PDGFR, Src. Smiles: Clc1ccc2[nH]c(=O)c(-c3nc4ccccc4[nH]3)c(N[C@@H]3CN4CCC3CC4)c2c1. References: Tse AN,...
| Schlagworte: | CHIR124, CHIR 124 |
| Anwendung: | Cell-permeable Chk1 inhibitor |
| CAS | 405168-58-3 |
| MW: | 419.91 D |
ab 37,00 €
CHIR124
Artikelnummer: Cay16553-1
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. CHIR124 is a cell-permeable, quinolone-based inhibitor of Chk1 (IC50 = 0.3 nM in vitro). It demonstrates high selectivity for Chk1 by displaying inhibitory values 2,000-fold higher against Chk2 (IC50 = 0.7 µM). In...
| Schlagworte: | 4-[(3S)-1-azabicyclo[2.2.2]oct-3-ylamino]-3-(1H-benzimidazol-2-yl)-6-chloro-2(1H)-quinolinone |
| Anwendung: | Cell-permeable Chk1 inhibitor |
| CAS | 405168-58-3 |
| MW: | 419.9 D |
ab 49,00 €
