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W-54011
Artikelnummer: TGM-T17250-100mg
Description: W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki = 2.2 nM). W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophils (IC50s = 3.1 nM, 2.7 nM, and 1.6 nM,...
| Anwendung: | C5a Receptor Antagonist |
| CAS | 405098-33-1 |
| MW: | 493.08 D |
ab 77,00 €
W-54011
Artikelnummer: Cay21231-1
W-54011 is an orally bioavailable, nonpeptide antagonist of complement component 5a receptor 1 (C5aR), also known as cluster of differentiation 88 (CD88). W-54011 inhibits 125I-rhC5a binding in neutrophils (Ki = 2.2 nM) and C5a-mediated intracellular Ca2+ mobilization (IC50 = 3.1 nM). W-54011 is selective and does...
| Schlagworte: | N-[[4-(dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide,... |
| Anwendung: | C5a Receptor Antagonist |
| CAS | 405098-33-1 |
| MW: | 493.1 D |
ab 55,00 €
