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PD 0325901
Artikelnummer: Cay13034-25
The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. PD 0325901 is a potent MEK inhibitor that suppresses phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 0.33 nM. Suppression of ERK activation...
| Schlagworte: | N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide |
| Anwendung: | MEK inhibitor |
| CAS | 391210-10-9 |
| MW: | 482.2 D |
ab 58,00 €
PD 325901, Free Base (MEK1/2 Inhibitor III, PD0325901,...
Artikelnummer: LC-P-9688_5mg
Soluble in DMSO at 12 mg/mL, soluble in ethanol at 6.3 mg/mL with slight warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 50-100 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility
| Schlagworte: | N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide |
| Anwendung: | MEK inhibitor |
| CAS | 391210-10-9 |
| MW: | 482,19 D |
ab 88,00 €
PD 0325901
Artikelnummer: AG-CR1-3711-M001
White to off-white solid. Soluble in DMSO (20mg/ml) or ethanol (15mg/ml). Chemical. CAS: 391210-10-9. Formula: C16H14F3IN2O4. MW: 482.2. PD 0325901 is a potent and selective non-ATP competitive orally active MEK1 and MEK2 inhibitor. In comparison to the CI-1040 MEK inhibitor that PD 0325901 has a greater potency of...
| Schlagworte: | Mirdametinib, N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide |
| CAS | 391210-10-9 |
| MW: | 482,2 D |
ab 28,00 €
PD325901
Artikelnummer: LKT-P1202.100
A potent inhibitor of MEK, a key component of the Mitogen activated protein kinase (MAPK) cascade. It has been found to inhibit tumor cell growth, has antiangiogenic and antiproliferative activities.
| Anwendung: | MEK inhibitor |
| CAS | 391210-10-9 |
| MW: | 482,19 D |
ab 192,00 €
