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PK11000
Artikelnummer: TGM-T4459-100mg
Description: PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53. Target: DNA Alkylator/Crosslinker. Smiles: CS(=O)(=O)c1ncc(Cl)c(n1)C(O)=O. References: Bauer MR, et al. 2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells....
| Anwendung: | Mutant p53 stabilizer |
| CAS | 38275-34-2 |
| MW: | 236.63 D |
ab 32,00 €
PK11000
Artikelnummer: Cay37306-100
PK11000 is a stabilizer of mutant p53. It covalently binds to Cys182 and Cys277, increases the thermal stability, and inhibits the aggregation of the p53Y220C DNA-binding domain when used at a concentration of 1 mM. PK11000 selectively decreases the viability of mutant p53-expressing SW480 (p53R273H,P309S), NUGC-3...
| Schlagworte: | 5-chloro-2-(methylsulfonyl)-4-pyrimidinecarboxylic acid |
| Anwendung: | Mutant p53 stabilizer |
| CAS | 38275-34-2 |
| MW: | 236.6 D |
ab 115,00 €
