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SB-649868
Artikelnummer: TGM-T5498-100mg
Description: SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively). Target: OX Receptor. Smiles: Cc1nc(C(=O)N2CCCC[C@H]2CNC(=O)c2cccc3occc23)c(s1)-c1ccc(F)cc1. References: Faedo S, et al. Functional and binding kinetic studies...
| Schlagworte: | GSK649868 |
| Anwendung: | Orexin receptor (Ox-1-R, Ox-2-R) antagonist |
| CAS | 380899-24-1 |
| MW: | 477.55 D |
ab 31,00 €
SB-649868
Artikelnummer: Cay29477-1
SB-649868 is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 0.31 and 0.39 nM, respectively). In vivo, SB-649868 (3 and 10 mg/kg) decreases wakefulness and latency to fall asleep in rats. It also reduces binge eating of highly palatable food in a female rat model of stress-induced binge eating.Formal...
| Schlagworte: | GSK 649868, N-[[(2S)-1-[[5-(4-fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-piperidinyl]methyl]-4-benzofurancarboxamide |
| Anwendung: | Orexin receptor (Ox-1-R, Ox-2-R) antagonist |
| CAS | 380899-24-1 |
| MW: | 477.6 D |
ab 44,00 €
