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Bosutinib
Artikelnummer: Cay12030-5
Bosutinib is an inhibitor of c-Src and Abl kinases (IC50s = 1.2 and 1 nM, respectively). It also inhibits the kinases EPHB2, TrkA, TrkB, and TXK (IC50s = 8.5, 22, 27, and 40 nM, respectively) among others. Bosutinib inhibits Src-dependent cell proliferation (IC50 = 100 nM) and reverses Src-transformed fibroblasts to...
| Schlagworte: | SKI 606, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile |
| Anwendung: | c-Src and Abl inhibitor |
| CAS | 380843-75-4 |
| MW: | 530.5 D |
ab 67,00 €
Bosutinib
Artikelnummer: TGM-T0152-10mg
Description: Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases. Target: Autophagy, Bcr-Abl, Src. Smiles: N(C=1C2=C(C=C(OCCCN3CCN(C)CC3)C(OC)=C2)N=CC1C#N)C4=CC(OC)=C(Cl)C=C4Cl. References: Boschelli DH, et al....
| Schlagworte: | SKI-606 |
| CAS | 380843-75-4 |
| MW: | 530.45 D |
ab 32,00 €
Bosutinib
Artikelnummer: LKT-B5874.10
Src and Abl inhibitor.
| Schlagworte: | SKI-606, 4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile |
| Anwendung: | Abl tyrosine kinase inhibitor, src tyrosine kinase inhibitor |
| CAS | 380843-75-4 |
| MW: | 530.45 D |
ab 157,00 €
