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IC-87114
Artikelnummer: Cay11589-1
IC-87114 is a cell-permeable selective inhibitor of the PI3K catalytic subunit p110delta (IC50 = 0.5 µM). It less effectively inhibits p110gamma and p110beta (IC50 = 29 and 75 µM, respectively) and has no significant effect on p110alpha and several other kinases. This product is used to elucidate the role of...
| Schlagworte: | 2-[(6-amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone |
| Anwendung: | PIK3CD inhibitor |
| CAS | 371242-69-2 |
| MW: | 397.4 D |
ab 60,00 €
IC87114
Artikelnummer: SYN-1045-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. IC87114 is a potent, ATP-competitive, and selective inhibitor of PI3Kdelta. IC(50) values (130-500nM) for IC87114 are sub-micromolar over a wide range of ATP concentrations from 10µM to 200µM. IC87114 can selectively inhibit cellular migration but not...
| Schlagworte: | IC-87114 |
| Anwendung: | PI3K delta inhibitor |
| CAS | 371242-69-2 |
| MW: | 397,4 D |
ab 79,00 €
IC-87114
Artikelnummer: LKT-I0800.1
IC-87114 is an inhibitor of p110 PI3K that exhibits anti-inflammatory, immunosuppressive, anti-asthma, anti-angiogenic, and anti-diabetic activities. In animals, IN-87114 inhibits airway infiltration of lymphocytes, neutrophils, and eosinophils, decreases expression of IL-4, IL-5, IL-13, and IL-17, and prevents...
| Anwendung: | PIK3CD inhibitor |
| CAS | 371242-69-2 |
| MW: | 397.43 D |
ab 84,00 €
