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API-1
Artikelnummer: Cay22081-1
API-1 is an inhibitor of Akt that reduces the level of phosphorylated Akt (IC50 = ~0.8 µM in OVCAR3 cells) by binding to Akt and blocking its translocation to the cell membrane. It reduces cell proliferation in various cancer cell lines, induces apoptosis, and, at a dose of 10 mg/kg per day, decreases tumor growth...
| Schlagworte: | NSC 177223, 4-amino-5,8-dihydro-5-oxo-8-beta-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide |
| Anwendung: | AKT inhibitor |
| CAS | 36707-00-3 |
| MW: | 337.3 D |
ab 52,00 €
API-1
Artikelnummer: TGM-T8969-100mg
Description: API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, beta-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis . Target: Akt, Apoptosis. Smiles: NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c2c1=O. References: Ren H , Koo J , Guan B , et al....
| Schlagworte: | NSC177223 |
| Anwendung: | AKT inhibitor |
| CAS | 36707-00-3 |
| MW: | 337.29 D |
ab 51,00 €
