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NVP-231
Artikelnummer: Cay13858-1
NVP-231 is a potent and reversible inhibitor of ceramide kinase (IC50 = 12 nM). It is selective for ceramide kinase over SPHK1, SPHK2, DAGKa, PI3Ka, PI4Kb, VPS34, GCS, SMS-1, and CERT (IC50s = >5 mM). NVP-231 inhibits formation of ceramide-1-phosphate (C1P, IC50 = 10 nM) and cell death in ceramide kinase...
| Schlagworte: | N-[2-(benzoylamino)-6-benzothiazolyl]-tricyclo[3.3.1.13,7]decane-1-carboxamide |
| Anwendung: | Ceramide kinase inhibitor |
| CAS | 362003-83-6 |
| MW: | 431.6 D |
ab 51,00 €
NVP 231
Artikelnummer: TGM-T1933-100mg
Description: NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK. Target: Apoptosis, ERK. Smiles: O=C(Nc1nc2ccc(NC(=O)C34CC5CC(CC(C5)C3)C4)cc2s1)c1ccccc1. References: Graf C, et al.Mol Pharmacol. 2008 Oct,74(4):925-32.
| Anwendung: | Ceramide kinase inhibitor |
| CAS | 362003-83-6 |
| MW: | 431.55 D |
ab 30,00 €
