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SB-505124 hydrochloride
Artikelnummer: TGM-T21637-5mg
Description: SB-505124 hydrochloride (SB505124 hydrochloride) is an orally available, selective and potent inhibitor of TGF-beta type I receptors (ALK4, ALK5, ALK7) with IC50 values of 129 nM and 47 nM for ALK4 and ALK5, respectively. SB-505124 hydrochloride inhibits IL-6 production by synovial explants and reduces...
| Schlagworte: | SB505124 hydrochloride, SB 505124 hydrochloride |
| CAS | 356559-13-2 |
| MW: | 371.86 D |
ab 34,00 €
SB-505124 (hydrochloride)
Artikelnummer: Cay42056-1
An ALK5 and ALK4 inhibitor (IC50s = 47 and 129 nM, respectively), selective for ALK5 and ALK4 over a panel of 27 kinases at 10 µM, inhibits ALK7-induced increases in phosphorylated SMAD2 levels in COS-1 cells overexpressing ALK7 at 5 µM, inhibits TGF-beta-induced but not TNF-alpha-induced apoptosis in Fao cells at 1...
| Schlagworte: | TGF-beta Receptor Type I Kinase Inhibitor III, TGF-beta RI Kinase Inhibitor III,... |
| Anwendung: | ALK5 / ALK4 inhibitor |
| CAS | 356559-13-2 |
| MW: | 371.9 D |
ab 40,00 €
