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LY456236 (hydrochloride)
LY456236 (hydrochloride)

Artikelnummer: Cay42263-1

An antagonist of mGluR1 (IC50 = 140 nM), reduces the growth of PC-9 cells and PC-9-AMG cells in MGS co-culture but not in monoculture, reduces MGS co-culture-induced increases in EGFR levels in PC-9-AMG cells, reduces tumor growth in a PC-9-AMG mouse model of brain metastasis at 50 mg/kg per day, inhibits seizures...
Schlagworte: MPMQ, 6-methoxy-N-(4-methoxyphenyl)-4-quinazolinamine, monohydrochloride
Anwendung: mGluR1 antagonist
CAS 338736-46-2
MW: 317.8 D
ab 40,00 €
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LY 456236 hydrochloride
LY 456236 hydrochloride

Artikelnummer: TGM-T22954-100mg

Description: LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 µM. LY 456236 hydrochloride inhibited EGFR with IC50 of 0.91 µM....
Schlagworte: MPMQ hydrochloride
CAS 338736-46-2
MW: 317.77 D
ab 33,00 €
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