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CUR 61414
Artikelnummer: Cay14931-10
CUR 61414 is a potent inhibitor of hedgehog-induced cellular activity (IC50 = 100-200 nM). It binds directly with the pathway activator Smoothened (Ki = 44 nM). CUR 61414 blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of basaloid lesions triggered by ultraviolet light...
| Schlagworte: | G-856,... |
| Anwendung: | Smoothened antagonist |
| CAS | 334998-36-6 |
| MW: | 550.7 D |
ab 178,00 €
CUR61414
Artikelnummer: TGM-T15019-100mg
Description: CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM). Target: Hedgehog/Smoothened. Smiles: COc1cccc(CN([C@H]2C[C@H](N(Cc3ccc4OCOc4c3)C2)C(=O)N2CCNCC2)C(=O)CC(C)(C)C)c1. References: Williams JA, et al. Identification of a...
| Anwendung: | Smoothened antagonist |
| CAS | 334998-36-6 |
| MW: | 550.69 D |
ab 46,00 €
