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ZM 447439
Artikelnummer: Cay13601-10
The Aurora kinases have important roles in regulating mitosis and cytokinesis, with Aurora B involved in centromere function as part of the Chromosomal Passenger Complex, with survivin, INCENP, and borealin. ZM 447439 is a selective inhibitor of Aurora B kinase (IC50 = 50 nM), less potently inhibiting Aurora C and A...
| Schlagworte: | N-[4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]-benzamide |
| Anwendung: | Aurora B kinase inhibitor |
| CAS | 331771-20-1 |
| MW: | 513.6 D |
ab 92,00 €
ZM-447439
Artikelnummer: TGM-T6077-10mg
Description: ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc. Target: Aurora Kinase, Apoptosis, MEK, Src....
| Anwendung: | Aurora B kinase inhibitor |
| CAS | 331771-20-1 |
| MW: | 513.59 D |
ab 43,00 €
ZM447439
Artikelnummer: LKT-Z4900.1
ZM447439 inhibits aurora kinases A and B (AurA, AurB), preventing mitotic spindle formation and proper completion of mitosis. This compound exhibits anticancer activity, inducing hyperploidy and apoptosis in osteosarcoma cells and inhibiting growth in mesothelioma cells. ZM447439 also induces apoptosis and inhibits...
| Anwendung: | Aurora A / B kinase inhibitor |
| CAS | 331771-20-1 |
| MW: | 567.63 D |
ab 136,00 €
