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MK-0557
Artikelnummer: TGM-TQ0286-100mg
Description: MK-0557 is a selective and orally available antagonist of the neuropeptide Y5 receptor (Ki: 1.6 nM). Target: Neuropeptide Y Receptor. Smiles: Fc1ccccc1-n1ccc(NC(=O)[C@H]2CC[C@]3(CC2)OC(=O)c2ccncc32)n1. References: Fichtner M, et al. Discovery and evaluation of spirocyclic derivatives as antagonists of...
| Anwendung: | NPY5R antagonist |
| CAS | 328232-95-7 |
| MW: | 406.41 D |
ab 46,00 €
MK-0557
Artikelnummer: Cay22134-1
MK-0557 is a potent antagonist of the neuropeptide Y (NPY) receptor Y5 (Kis = 1.3, 0.79, 0.74, and 1.4 nM for human, rhesus monkey, mouse, and rat receptors, respectively). It is >7,500-fold selective for Y5 over other receptors and lacks activity in a panel of 180 receptors, enzymes, and ion channels at...
| Schlagworte: | trans-N-[1-(2-fluorophenyl)-1H-pyrazol-3-yl]-1'-oxo-spiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide |
| Anwendung: | NPY5R antagonist |
| CAS | 328232-95-7 |
| MW: | 406.4 D |
ab 52,00 €
