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L67
Artikelnummer: Cay22941-10
L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 µM for human DNA ligase I and human ligase IIIbeta). It blocks DNA binding (Ki = 10 µM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIalpha and induces the production of reactive oxygen...
| Schlagworte: | N-(3,5-dibromo-4-methylphenyl)-glycine, 2-[(2-hydroxy-5-nitrophenyl)methylene]hydrazide |
| Anwendung: | DNA ligase I / III inhibitor |
| CAS | 325970-71-6 |
| MW: | 486.1 D |
ab 145,00 €
L67
Artikelnummer: TGM-T3103-100mg
Description: L67 (DNA Ligase Inhibitor) is a competitive inhibitor of human DNA ligases I and III with an IC50 of 10 µM. Target: DNA/RNA Synthesis, DNA. Smiles: Cc1c(Br)cc(NCC(=O)N\N=C\c2cc(ccc2O)[N+]([O-])=O)cc1Br. References: Chen X, et al. Y Res. 2008 May 1,68(9):3169-3177.
| Schlagworte: | DNA Ligase Inhibitor |
| Anwendung: | DNA ligase I / III inhibitor |
| CAS | 325970-71-6 |
| MW: | 486.11 D |
ab 41,00 €
